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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
09/12/2021 |
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Data da última atualização: |
09/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LOPES, P. D.; OKINO, C. H.; FERNANDO, F. S.; PAVANI, C.; MARIGUELA, V. C.; MONTASSIER, M. DE F. S.; MONTASSIER, H. J. |
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Afiliação: |
PRISCILA DINIZ LOPES, UNESP; CINTIA HIROMI OKINO, CPPSE; FILIPE SANTOS FERNANDO, UNESP; CAREN PAVANI, UNESP; VIVIANE CASAGRANDE MARIGUELA, UNESP; MARIA DE FÁTIMA SILVA MONTASSIER, UNESP; HÉLIO JOSÉ MONTASSIER, UNESP. |
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Título: |
Comparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Vaccines, v.9, n.12, 1457, 2021. |
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ISSN: |
2076-393X |
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DOI: |
https://doi.org/10.3390/vaccines9121457 |
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Idioma: |
Inglês |
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Conteúdo: |
Efficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection. MenosEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vacci... Mostrar Tudo |
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Palavras-Chave: |
Avian infectious bronchitis; Cellular immune response; Delivery carrier adjuvant; Mucosal immunization; Oil adjuvant. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/228815/1/ComparativeEvaluationImmune.pdf
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Marc: |
LEADER 02553naa a2200277 a 4500
001 2137397
005 2021-12-09
008 2021 bl uuuu u00u1 u #d
022 $a2076-393X
024 7 $ahttps://doi.org/10.3390/vaccines9121457$2DOI
100 1 $aLOPES, P. D.
245 $aComparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens.$h[electronic resource]
260 $c2021
520 $aEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection.
653 $aAvian infectious bronchitis
653 $aCellular immune response
653 $aDelivery carrier adjuvant
653 $aMucosal immunization
653 $aOil adjuvant
700 1 $aOKINO, C. H.
700 1 $aFERNANDO, F. S.
700 1 $aPAVANI, C.
700 1 $aMARIGUELA, V. C.
700 1 $aMONTASSIER, M. DE F. S.
700 1 $aMONTASSIER, H. J.
773 $tVaccines$gv.9, n.12, 1457, 2021.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| Registros recuperados : 22 | |
| 1. |  | CARVALHO, L. O. D. de M.; COSTA, N. A. da; LOURENCO JUNIOR, J. de B.; TEIXEIRA NETO, J. F.; SANTOS, N. F. A.; MONTEIRO, E. M. M. Integrated system of buffaloes raising on the small farm in eastern Amazon. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 513-517.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 2. | | CARVALHO, L. O. D. de M.; LOURENCO JUNIOR, J. de B.; COSTA, N. A. da; TEIXEIRA NETO, J. F.; BAENA, A. R. C.; SANTOS, N. F. A.; MONTEIRO, E. M. M. Supplemental feeding for buffaloes fattening on intensive rotationed system, in Belem, Para State, Brazil. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 404-406.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 3. | | CONTARINI, L. B. P.; SOARES, B. C.; RODRIGUES FILHO, J. A.; SENA, A. L. S.; LOURENÇO JUNIOR, J. B.; SANTOS, N. F. A. Manejo sanitário da pecuária leiteira do município de Rondon do Pará. In: CONGRESSO DE ZOOTECNIA DA AMAZÔNIA, 2., 2015, Araguaína. [Anais]. Araguaína: UFT, 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 4. | | COSTA, N. A. da; CARVALHO, L. O. D. de M.; LOURENCO JUNIOR, J. de B.; TEIXEIRA NETO, J. F.; SANTOS, N. F. A.; MONTEIRO, E. M. M. Ponderal performance of buffaloes chemically castrated, in Belém, Pará State, Brazil. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 502-505. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 5. | | COSTA, N. A. da; LOURENÇO JÚNIOR, J. de B.; TEIXEIRA NETO, J. F.; BAENA, A. R. C.; SANTOS, N. F. A.; MONTEIRO, E. M. M. Buffalo meat production on intensive rotationed grazing system on Castanhal, Pará State, Brazil. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém. Proceedings of the... Belém: APCB: FCAP, 2002. p. 393-395. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 6. | | COSTA, N. A. da; LOURENCO JUNIOR, J. de B.; TEIXEIRA NETO, J. F.; LAU, H. D.; MARQUES, J. R. F.; CARVALHO, L. O. D. de M.; SANTOS, N. F. A.; MONTEIRO, E. M. M. Weight gain of Murrah buffaloes in system of intensive rotationed grazing with supplemental feeding in Para State, Brazil. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 396-398. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 7. | | COSTA, N. A. da; LOURENCO JUNIOR, J. de B.; TEIXEIRA NETO, J. F.; SANTOS, N. F. A.; MONTEIRO, E. M. M. Intensive buffaloes meat production in confinement, in Para State, Brazil. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém. Proceedings of the... Belém: APCB: FCAP, 2002. p. 399-401. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 8. | | DANTAS, J. A. S.; LOURENÇO JÚNIOR, J. B.; MONTEIRO, E. M. M.; SANTOS, N. F. A.; AVIZ, M. A. B.; COSTA, D. A. Variáveis climáticas vs. concepção de búfalas na Amazônia (climatic variable vs. conception of buffalos in the Amazônia). Archivos de Zootecnia, v. 57, n. 219, p. 349-351, 2008. Título em inglês: Climatic variable vs. conception of buffalos in the Amazônia. Disponível também on-line.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - C |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 9. | | GARCIA, A. R.; MORAES JÚNIOR, R. J.; SANTOS, N. F. A.; LOURENÇO JUNIOR, J. B.; NAHUM, B. de S. Morphometric characterization and ponderal performance of buffalo calves raised on Brazilian Amazon. Revista Veterinaria, v. 21, supl. 1, p. 796-798, 2010. Proceeding of World Buffalo Congress, 9., 2010, Buenos Aires.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 10. | | LOURENÇO JUNIOR, J. B.; GARCIA, A. R.; NAHUM, B. de S.; SANTOS, N. F. A.; BASTOS, R. O. F. Zootechnic processes control system, monitoring and management of the buffalo meat. Revista Veterinaria, v. 21, supl. 1, p. 536-538, 2010. Proceeding of World Buffalo Congress, 9., 2010, Buenos Aires.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 11. | | LOURENCO JUNIOR, J. de B.; COSTA, N. A. da; TEIXEIRA NETO, J. F.; BAENA, A. R. C.; CARVALHO, L. O. D. de M.; SANTOS, N. F. A.; MONTEIRO, E. M. M. Ponderal performance of buffaloes in intensive rotationed grazing with supplementation of aminoacids, minerals and vitamins, Pará State, Brazil. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 402-403.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 12. | | LOURENÇO JÚNIOR, J. de B.; LOURENÇO, L. F. H.; AMANJÁS, C. C.; SOUSA, C. L.; COSTA, N. A. da; CARVALHO, L. D. de M.; SANTOS, N. F. A. Income and physical-chemiscal characteristics of "babyburger" elaborated with secondary cut of "baby buffalo". In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 564-566. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 13. | | LOURENÇO JÚNIOR, J. de B.; LOURENÇO, L. F. H.; AMANJÁS, C. C.; SOUSA, C. L.; COSTA, N. A. da; CARVALHO, L. O. D. de M.; SANTOS, N. F. A. Income evaluation and physical-chemical characteristics of sun meat elaborated with secondary cut of "baby buffalo". In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 558-560. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 14. | | LOURENÇO JÚNIOR, J. de B.; LOURENÇO, L. F. H.; AMANJÁS, C. C.; SOUSA, C. L.; COSTA, N. A. da; CARVALHO, L. O. D. de M.; SANTOS, N. F. A. Microbiological and sensorial characteristics of "babyburger" elaborated with secondary cut of baby buffalo. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 567-569. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 15. | | LOURENÇO JÚNIOR, J. de B.; LOURENÇO, L. F. H.; AMANJÁS, C. C.; SOUSA, C. L.; COSTA, N. A. da; CARVALHO, L. O. D. de M.; SANTOS, N. F. A. Microbiological and sensorial evaluation of the characteristics of sun meat elaborated with secondary cut of "baby buffalo". In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 561-563. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 16. | | LOURENÇO JÚNIOR, J. de B.; LOURENÇO, V. V.; COSTA, N. A. da; CARVALHO, L. O. D. de M.; LOURENÇO, L. F. H.; SOUSA, C. L.; SANTOS, N. F. A. Evaluation of carcass income and physical-chemical characteristics of the "baby buffalo" meat. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 573-575. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 17. | | LOURENÇO JÚNIOR, J. de B.; LOURENÇO, V. V.; LOURENÇO, L. F. H.; SOUSA, C. L.; COSTA, N. A. da; CARVALHO, L. O. D. de M.; SANTOS, N. F. A. Microbiological and sensorial evaluation of the "baby búfalo" meat. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 570-572. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 18. | | LOURENÇO JÚNIOR, J. de B.; SANTOS, N. H. A.; BEMMUYAL, H. C. A.; LOURENÇO, L. F. H.; AMANJÁS, C. C.; SOUSA, C. L.; COSTA, N. A. da; CARVALHO, L. O. D. de M.; SANTOS, N. F. A. Cured sausage elaborated with secondary cut of "baby buffalo" income and physical-chemical characteristics.. In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 576-577. il.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 19. | | LOURENÇO JÚNIOR, J. de B.; SANTOS, N. H. A.; BEMMUYAL, H. C. A.; LOURENÇO, L. F. H.; AMANJÁS, C. C.; SOUSA, C. L.; COSTA, N. A. da; CARVALHO, L. O. D. de M.; SANTOS, N. F. A. Microbiological and sensorial evaluations of cured sausage elaborated with secondary cut of "Baby buffalo". In: BUFFALO SYMPOSIUM OF AMERICAS, 1., 2002, Belém, PA. Proceedings... Belém, PA: APCB: FCAP, 2002. p. 578-580.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 20. | | MORAES JÚNIOR, R. J.; GARCIA, A. R.; SANTOS, N. F. A.; LOURENÇO JUNIOR, J. B.; NAHUM, B. de S. Effects of the silvopastoral systems in the environmental comfort of buffalo calves (bubalus bubalis) in the eastern amazon. Revista Veterinaria, v. 21, supl. 1, p. 788-791, 2010. Proceeding of World Buffalo Congress, 9., 2010, Buenos Aires.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| Registros recuperados : 22 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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